Advancing glioblastoma research by establishing a whole brain slice model - Takeaways - MDSpire

Advancing glioblastoma research by establishing a whole brain slice model

  • By

  • Katharina Fuchs

  • Clara Keller

  • Bianca Layer

  • Katja Nadler

  • Ellaine Salvador

  • Tobias Weigel

  • Bastian Christ

  • Sofia Dembski

  • Ralf-Ingo Ernestus

  • Mario Löhr

  • Carsten Hagemann

  • June 24, 2026

  • 0 min

Share

  • 1

    A whole, large-format brain slice model was developed to enhance glioblastoma research by preserving complex cellular architecture.

  • 2

    The model utilizes 6-9-day-old postnatal mice, allowing for reduced animal usage by sectioning brains into multiple slices.

  • 3

    Brain slices maintained viability for 7-14 days and served as carrier tissue for glioblastoma cell spheroids.

  • 4

    Fluorescence-based methods, including the AlamarBlue assay, were employed to assess slice viability and tumor invasion patterns.

  • 5

    The model provides a more physiologically relevant platform for studying glioblastoma biology and therapeutic approaches.

Original Source(s)

Advancing glioblastoma research by establishing a whole brain slice model

  • by Katharina Fuchs, Clara Keller, Bianca Layer, Katja Nadler, Ellaine Salvador, Tobias Weigel, Bastian Christ, Sofia Dembski, Ralf-Ingo Ernestus, Mario Löhr, Carsten Hagemann

  • June 24, 2026

Related Content

Adjuvant radiotherapy for WHO grade II meningiomas: the unanswered question

MRI characteristics of cervical radioiodine-avid lymph nodes detected on post-therapeutic ¹³¹I whole-body scintigraphy in differentiated thyroid carcinoma

The lactate–lactylation axis in tumor radioresistance: metabolic, epigenetic, and immune mechanisms with emerging links to RNA regulation