Longitudinal assessment of intraocular pressure in the 5xFAD mouse model of Alzheimer's disease - Takeaways - MDSpire

Long-term Evaluation of Intraocular Pressure in the 5xFAD Mouse Model of Alzheimer's Disease

  • By

  • Raz Rubinshtein

  • Basel Obied

  • Talal Salti

  • Andres I. König

  • Alon Zahavi

  • Nitza Goldenberg-Cohen

  • July 21, 2026

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  • 1

    The study assessed intraocular pressure (IOP) in the 5xFAD mouse model of Alzheimer's disease to explore links between AD and glaucoma.

  • 2

    Aged 5xFAD mice showed transient IOP fluctuations, with a significant decrease at day 36 compared to age-matched wild type controls.

  • 3

    IOP remained stable across most groups and time points, indicating no sustained elevation in 5xFAD mice compared to wild type.

  • 4

    The findings suggest that amyloid pathology in 5xFAD mice does not drive chronic ocular hypertension.

  • 5

    Visual dysfunction in Alzheimer's models may occur independently of elevated intraocular pressure, warranting further investigation.

Original Source(s)

Longitudinal assessment of intraocular pressure in the 5xFAD mouse model of Alzheimer's disease

  • by Raz Rubinshtein, Basel Obied, Talal Salti, Andres I. König, Alon Zahavi, Nitza Goldenberg-Cohen

  • July 21, 2026

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