Ancestry informative genetic variants associated with tobacco metabolic and detoxification capacity measured by 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol (NNAL) among smokers - Takeaways - MDSpire

Ancestry informative genetic variants associated with tobacco metabolic and detoxification capacity measured by 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol (NNAL) among smokers

  • By

  • Oladimeji Lanade

  • Zhongxuan He

  • Yan Zhou

  • Elizabeth Blackman

  • Denise Gibbs

  • Sharon Harrison

  • Karthik Devarajan

  • Mark Andrake

  • Roland L. Dunbrack

  • Gerald Nkogbu

  • Aditi Wagh

  • Michael Slifker

  • Cherie Erkmen

  • Freda Patterson

  • Aditi Satti

  • Heather-Dawn Lawson-Myers

  • Robin Roberts

  • Don Mitchell

  • Jeffery C. Liu

  • Joel Erblich

  • Camille Ragin

  • July 14, 2026

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  • 1

    Tobacco use is the leading avoidable cause of cancer mortality, responsible for 26% of total cancer deaths globally in 2019.

  • 2

    Lung cancer incidence and mortality rates vary significantly among different demographics, particularly between Black and White males in the U.S.

  • 3

    Genetic ancestry factors may contribute to differences in tobacco-related cancer incidence between Black and White Americans.

  • 4

    The study investigates the association of genetic ancestry with tobacco metabolism efficiency, focusing on NNAL metabolites in smokers.

  • 5

    Participants in the study included current smokers aged 18 or older, recruited through community outreach and clinical settings.

Original Source(s)

Ancestry informative genetic variants associated with tobacco metabolic and detoxification capacity measured by 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol (NNAL) among smokers

  • by Oladimeji Lanade, Zhongxuan He, Yan Zhou, Elizabeth Blackman, Denise Gibbs, Sharon Harrison, Karthik Devarajan, Mark Andrake, Roland L. Dunbrack, Gerald Nkogbu, Aditi Wagh, Michael Slifker, Cherie Erkmen, Freda Patterson, Aditi Satti, Heather-Dawn Lawson-Myers, Robin Roberts, Don Mitchell, Jeffery C. Liu, Joel Erblich, Camille Ragin

  • July 14, 2026

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