Gut microbiota-dependent mechanisms and efficacy of natural polysaccharides in multitarget antidepressant therapy: a systematic review - Takeaways - MDSpire

Gut microbiota-dependent mechanisms and efficacy of natural polysaccharides in multitarget antidepressant therapy: a systematic review

  • By

  • Haoqi Liu

  • Min Wang

  • Chen Bai

  • Jingchun Li

  • Kaiqiang Dong

  • Rongjuan Guo

  • June 29, 2026

  • 0 min

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  • 1

    Natural polysaccharides may improve depression through modulation of gut microbiota and related metabolic pathways.

  • 2

    Twenty preclinical studies indicated that polysaccharide treatment improved depression-like behaviors and normalized neurotransmitter levels.

  • 3

    Polysaccharides were associated with reduced inflammation and oxidative stress, alongside changes in gut microbiota composition.

  • 4

    The evidence for the antidepressant effects of natural polysaccharides is preliminary and limited by high risk of bias in studies.

  • 5

    Further well-designed translational and clinical studies are necessary to validate the antidepressant potential of natural polysaccharides.

Original Source(s)

Gut microbiota-dependent mechanisms and efficacy of natural polysaccharides in multitarget antidepressant therapy: a systematic review

  • by Haoqi Liu, Min Wang, Chen Bai, Jingchun Li, Kaiqiang Dong, Rongjuan Guo

  • June 29, 2026

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