Investigating Molecular Reactions to Radiofrequency Microneedling in a 3D Human Skin Model: Insights and Influence of Post-Treatment Care - Takeaways - MDSpire

Investigating Molecular Reactions to Radiofrequency Microneedling in a 3D Human Skin Model: Insights and Influence of Post-Treatment Care

  • By

  • Sebastian Huth

  • Yvonne Marquardt

  • Laura Huth

  • Sina Djahed

  • Jens Malte Baron

  • April 22, 2026

  • 0 min

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  • 1

    Radiofrequency microneedling (RFMN) enhances skin rejuvenation by delivering thermal injury to deeper skin layers while protecting the epidermis.

  • 2

    The study utilized a 3D human skin model to investigate the molecular and histological responses to RFMN treatment.

  • 3

    Post-treatment with a dexpanthenol-containing ointment improved wound healing and gene expression related to skin regeneration.

  • 4

    Transcriptomic analysis revealed an early pro-inflammatory response after RFMN, indicating controlled inflammation and skin renewal.

  • 5

    Findings support optimizing clinical protocols for RFMN, emphasizing the importance of post-treatment care for effective skin rejuvenation.

Original Source(s)

Investigating Molecular Reactions to Radiofrequency Microneedling in a 3D Human Skin Model: Insights and Influence of Post-Treatment Care

  • by Sebastian Huth, Yvonne Marquardt, Laura Huth, Sina Djahed, Jens Malte Baron

  • April 22, 2026

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