Markers of axonal injury in blood and tissue triggered by acute and chronic demyelination - Takeaways - MDSpire

Markers of axonal injury in blood and tissue triggered by acute and chronic demyelination

  • By

  • Ahmed Abdelhak

  • Christian Cordano

  • Greg J Duncan

  • Katie Emberley

  • Sonia Nocera

  • Wendy Xin

  • Kirtana Ananth

  • Nour Jabassini

  • Kiarra Ning

  • Henriette Reinsberg

  • Frederike Cosima Oertel

  • Alexandra Beaudry-Richard

  • Jens Kuhle

  • Axel Petzold

  • Praveen J Patel

  • Ana P Ribeiro Reis

  • Paul J Foster

  • UKBB Eye and Vision Consortium

  • Trent Watkins

  • Jonah R Chan

  • Ben Emery

  • Ari J Green

  • April 25, 2025

  • 0 min

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  • 1

    Neuroaxonal injury significantly contributes to irreversible disability in demyelinating diseases like multiple sclerosis.

  • 2

    Blood neurofilament light chain (NfL) levels correlate with axonal damage and demyelination severity in experimental autoimmune encephalitis.

  • 3

    NfL dynamics can be monitored longitudinally, showing peaks during demyelination and reductions following effective remyelination.

  • 4

    The study validates the association between NfL and myelin breakdown proteins in multiple sclerosis patients across two independent cohorts.

  • 5

    Findings suggest that changes in myelin integrity may influence NfL levels, independent of direct axonal structural damage.

Original Source(s)

Markers of axonal injury in blood and tissue triggered by acute and chronic demyelination

  • by Ahmed Abdelhak, Christian Cordano, Greg J Duncan, Katie Emberley, Sonia Nocera, Wendy Xin, Kirtana Ananth, Nour Jabassini, Kiarra Ning, Henriette Reinsberg, Frederike Cosima Oertel, Alexandra Beaudry-Richard, Jens Kuhle, Axel Petzold, Praveen J Patel, Ana P Ribeiro Reis, Paul J Foster, UKBB Eye and Vision Consortium, Trent Watkins, Jonah R Chan, Ben Emery, Ari J Green

  • April 25, 2025

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