Efficacy Comparison of Cycling Versus Transitioning to IL-17 Inhibitors Following Initial TNF Inhibitor Failure in Psoriatic Arthritis: A Multicenter Real-World Analysis - Takeaways - MDSpire

Efficacy Comparison of Cycling Versus Transitioning to IL-17 Inhibitors Following Initial TNF Inhibitor Failure in Psoriatic Arthritis: A Multicenter Real-World Analysis

  • By

  • Alarico Ariani

  • Maddalena Larosa

  • Alberto Lo Gullo

  • Olga Addimanda

  • Romina Andracco

  • Patrizia Del Medico

  • Marino Paroli

  • Maria Chiara Ditto

  • Bernd Raffeiner

  • Aurora Ianniello

  • Francesca Ometto

  • Marta Priora

  • Aldo Biagio Molica Colella

  • Elena Bravi

  • Viviana Ravagnani

  • Alessandra Bezzi

  • Rosetta Vitetta

  • Palma Scolieri

  • Alessandro Volpe

  • Federica Lumetti

  • Antonella Farina

  • Francesco Girelli

  • Elisa Visalli

  • Francesca Serale

  • Eleonora Celletti

  • Veronica Franchina

  • Francesco Molica Colella

  • Giulio Ferrero

  • Fabio Mascella

  • Maria Cristina Focherini

  • Alessia Fiorenza

  • Guido Rovera

  • Cecilia Giampietro

  • Simone Bernardi

  • Natalia Mansueto

  • Dario Camellino

  • Rosalba Caccavale

  • Valeria Nucera

  • Myriam Di Penta

  • Emanuela Sabatini

  • Ilaria Platè

  • Adorni Giuditta

  • Eleonora Di Donato

  • Daniele Santilli

  • Gianluca Lucchini

  • Mirco Magnani

  • Gianluca Smerilli

  • Giorgio Amato

  • Francesco De Lucia

  • Ylenia Dal Bosco

  • Roberta Foti

  • Francesco Cipollone

  • Gerolamo Bianchi

  • Rosario Foti

  • Eugenio Arrigoni

  • Antonio Marchetta

  • Vincenzo Bruzzese

  • Gilda Sandri

  • Enrico Fusaro

  • Massimo Reta

  • Dilia Giuggioli

  • Antonio Marchesoni

  • Simone Parisi

  • Andrea Becciolini

  • November 24, 2025

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  • 1

    This study compares the retention rates of TNF inhibitors and IL-17 inhibitors in psoriatic arthritis patients after TNFi failure.

  • 2

    The research involved 452 psoriatic arthritis patients treated at 25 Italian rheumatology centers from January 2016 to March 2024.

  • 3

    Patients were divided into two groups: cycling (TNFi to TNFi) and swapping (TNFi to IL-17i) based on their treatment strategy.

  • 4

    The primary outcome measured was treatment retention, with secondary outcomes assessing predictors of treatment discontinuation.

  • 5

    Statistical analyses included Kaplan-Meier curves and Cox analysis to evaluate factors influencing treatment persistence.

Original Source(s)

Efficacy Comparison of Cycling Versus Transitioning to IL-17 Inhibitors Following Initial TNF Inhibitor Failure in Psoriatic Arthritis: A Multicenter Real-World Analysis

  • by Alarico Ariani, Maddalena Larosa, Alberto Lo Gullo, Olga Addimanda, Romina Andracco, Patrizia Del Medico, Marino Paroli, Maria Chiara Ditto, Bernd Raffeiner, Aurora Ianniello, Francesca Ometto, Marta Priora, Aldo Biagio Molica Colella, Elena Bravi, Viviana Ravagnani, Alessandra Bezzi, Rosetta Vitetta, Palma Scolieri, Alessandro Volpe, Federica Lumetti, Antonella Farina, Francesco Girelli, Elisa Visalli, Francesca Serale, Eleonora Celletti, Veronica Franchina, Francesco Molica Colella, Giulio Ferrero, Fabio Mascella, Maria Cristina Focherini, Alessia Fiorenza, Guido Rovera, Cecilia Giampietro, Simone Bernardi, Natalia Mansueto, Dario Camellino, Rosalba Caccavale, Valeria Nucera, Myriam Di Penta, Emanuela Sabatini, Ilaria Platè, Adorni Giuditta, Eleonora Di Donato, Daniele Santilli, Gianluca Lucchini, Mirco Magnani, Gianluca Smerilli, Giorgio Amato, Francesco De Lucia, Ylenia Dal Bosco, Roberta Foti, Francesco Cipollone, Gerolamo Bianchi, Rosario Foti, Eugenio Arrigoni, Antonio Marchetta, Vincenzo Bruzzese, Gilda Sandri, Enrico Fusaro, Massimo Reta, Dilia Giuggioli, Antonio Marchesoni, Simone Parisi, Andrea Becciolini

  • November 24, 2025

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