Sjögren Disease—B Cells at the Brink: From Autoimmunity to Lymphomagenesis and the Rise of Novel B Cell–Targeted Therapies - Takeaways - MDSpire

Sjögren's Syndrome: The Role of B Cells in Autoimmunity, Lymphoma Development, and Emerging B Cell-Directed Treatments

  • By

  • Rachael A. Gordon

  • Sara S. McCoy

  • July 1, 2026

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  • 1

    A 39-year-old woman with a 15-year history of Sjögren's disease presented with recurrent parotid swelling and inflammatory arthritis.

  • 2

    Sjögren's disease is highly heterogeneous, affecting various organ systems and presenting with diverse symptoms beyond dryness.

  • 3

    Endotyping in Sjögren's disease identifies three main subgroups based on disease activity and symptom burden, aiding in understanding disease progression.

  • 4

    B cells are central to Sjögren's disease pathogenesis, producing autoantibodies and influencing T cell activity.

  • 5

    Future research aims to validate Sjögren's disease endotypes and their potential to guide therapeutic decisions.

Original Source(s)

Sjögren Disease—B Cells at the Brink: From Autoimmunity to Lymphomagenesis and the Rise of Novel B Cell–Targeted Therapies

  • by Rachael A. Gordon, Sara S. McCoy

  • July 1, 2026

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