Novel BPI3Vc-vectored chimeric BVDV antigens elicit broadly neutralizing antibodies in cattle - Takeaways - MDSpire

Novel BPI3Vc-vectored chimeric BVDV antigens elicit broadly neutralizing antibodies in cattle

  • By

  • Huldah Sang

  • Tae Kim

  • Rakshith Kumar

  • Jayden McCall

  • Aloysius Abraham

  • Tsvetoslav Koynarski

  • Michelle Zajac

  • Karim W. Abdelsalam

  • Daniela Hernandez Muguiro

  • Katherine Bauer

  • Brandon L. Plattner

  • Waithaka Mwangi

  • May 18, 2026

  • 0 min

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  • 1

    BVDV significantly contributes to Bovine Respiratory Disease complex, causing severe health issues and economic losses in the livestock industry.

  • 2

    Current vaccines provide limited protection against diverse BVDV strains, necessitating the development of a more effective vaccine.

  • 3

    The study developed a live-attenuated BPI3Vc-vectored vaccine using chimeric BVDV antigens to induce broad antibody responses.

  • 4

    Immunization with the rBPI3VcmutBVDV vaccine elicited significantly higher neutralizing titers against various BVDV strains compared to commercial vaccines.

  • 5

    Vaccinated calves showed improved health outcomes, including steady weight gain and reduced viremia, supporting the vaccine's efficacy.

Original Source(s)

Novel BPI3Vc-vectored chimeric BVDV antigens elicit broadly neutralizing antibodies in cattle

  • by Huldah Sang, Tae Kim, Rakshith Kumar, Jayden McCall, Aloysius Abraham, Tsvetoslav Koynarski, Michelle Zajac, Karim W. Abdelsalam, Daniela Hernandez Muguiro, Katherine Bauer, Brandon L. Plattner, Waithaka Mwangi

  • May 18, 2026

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