Identifying Risk Factors and Developing a Predictive Model for Lymph Node Metastasis in Clinical Stage IA Peripheral Non-Small Cell Lung Cancer: A Retrospective Analysis - Takeaways - MDSpire

Identifying Risk Factors and Developing a Predictive Model for Lymph Node Metastasis in Clinical Stage IA Peripheral Non-Small Cell Lung Cancer: A Retrospective Analysis

  • By

  • Zhimao Chen

  • Yaokun Wang

  • Minghui Shi

  • Kang Qi

  • Xiangzheng Liu

  • Shijie Zhang

  • November 10, 2025

  • 0 min

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  • 1

    Lung cancer is the leading cause of cancer-related mortality, with non-small cell lung cancer (NSCLC) comprising about 85% of cases.

  • 2

    Clinical stage IA NSCLC is characterized by tumors ≤ 3 cm without evidence of lymph node or distant metastasis, often treated with limited surgical resection.

  • 3

    15-20% of clinical stage IA NSCLC patients have lymph node metastases postoperatively, highlighting the need for preoperative risk assessment.

  • 4

    This study developed a logistic regression-based nomogram to identify risk factors for lymph node metastasis in clinical stage IA peripheral NSCLC.

  • 5

    The model's performance was evaluated using ROC analysis, calibration, and decision curve analysis to enhance surgical planning and outcomes.

Original Source(s)

Identifying Risk Factors and Developing a Predictive Model for Lymph Node Metastasis in Clinical Stage IA Peripheral Non-Small Cell Lung Cancer: A Retrospective Analysis

  • by Zhimao Chen, Yaokun Wang, Minghui Shi, Kang Qi, Xiangzheng Liu, Shijie Zhang

  • November 10, 2025

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