Loss of ST8Sia6 mediated α-2,8-linked di-sialylation enhances T cell-dependent antibody responses and promotes autoimmunity in aged mice - Takeaways - MDSpire

Loss of ST8Sia6 mediated α-2,8-linked di-sialylation enhances T cell-dependent antibody responses and promotes autoimmunity in aged mice

  • By

  • Ronja Brüchert

  • Michael Hinzpeter-Schmidt

  • Bettina Röder

  • Mareike Krause

  • Stefanie Brey

  • Thomas H. Winkler

  • Falk F. R. Buettner

  • Martina Mühlenhoff

  • Lars Nitschke

  • July 2, 2026

  • 0 min

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  • 1

    ST8Sia6 catalyzes the synthesis of α-2,8-linked di-sialyl motifs, influencing immune cell activation and interactions.

  • 2

    St8sia6 knockout mice exhibited normal B cell development but showed enhanced T cell-dependent proliferation and IgG1 responses.

  • 3

    Aged St8sia6-/- mice had increased populations of germinal center B cells and elevated anti-nuclear IgG autoantibodies, indicating autoimmunity.

  • 4

    The study identified CD45 as a carrier protein for O-acetylated α2,8-linked di-sialic acids on plasma cells.

  • 5

    Loss of ST8Sia6-mediated di-sialylation enhances T cell-dependent immune responses and promotes an autoimmune-like phenotype in aging.

Original Source(s)

Loss of ST8Sia6 mediated α-2,8-linked di-sialylation enhances T cell-dependent antibody responses and promotes autoimmunity in aged mice

  • by Ronja Brüchert, Michael Hinzpeter-Schmidt, Bettina Röder, Mareike Krause, Stefanie Brey, Thomas H. Winkler, Falk F. R. Buettner, Martina Mühlenhoff, Lars Nitschke

  • July 2, 2026

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