Estimating Zika Virus Seroprevalence in a Dengue Virus–Endemic Population: The Use of Blood Donors and Multiplex Serology to Monitor Arbovirus Outbreaks in the Dutch Caribbean - Takeaways - MDSpire
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Assessing Seroprevalence of Zika Virus in a Dengue-Endemic Community: Utilizing Blood Donor Samples and Multiplex Serology for Arbovirus Surveillance in the Dutch Caribbean

  • By

  • Louella M R Kasbergen

  • Reina S Sikkema

  • Felicity Chandler

  • Janko H G van Beek

  • Yaskara Halabi

  • Norédiz Lourents

  • Eugene G Maduro

  • Izzy Gerstenbluth

  • Ashley Duits

  • Marion P G Koopmans

  • May 27, 2025

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  • 1

    The study assessed Zika virus seroprevalence in Aruba and Curaçao using blood donor samples during ZIKV outbreaks from January 2016 to July 2017.

  • 2

    Seroprevalence of ZIKV antibodies was found to be 25% in Curaçao, significantly higher than 8% in Aruba, indicating regional differences in exposure.

  • 3

    Multiplex serology and virus neutralization tests were utilized to differentiate ZIKV exposure from other flavivirus infections despite antibody cross-reactivity.

  • 4

    Flavivirus immunoglobulin G antibody titers increased with age, highlighting the importance of considering age in serology data interpretation.

  • 5

    The study emphasizes the value of voluntary blood donor programs for monitoring arbovirus outbreaks and understanding complex antibody patterns.

Original Source(s)

Estimating Zika Virus Seroprevalence in a Dengue Virus–Endemic Population: The Use of Blood Donors and Multiplex Serology to Monitor Arbovirus Outbreaks in the Dutch Caribbean

  • by Louella M R Kasbergen, Reina S Sikkema, Felicity Chandler, Janko H G van Beek, Yaskara Halabi, Norédiz Lourents, Eugene G Maduro, Izzy Gerstenbluth, Ashley Duits, Marion P G Koopmans

  • May 27, 2025

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