Prediction model for early left ventricular systolic dysfunction progression in hypertrophic cardiomyopathy - Takeaways - MDSpire

Prediction model for early left ventricular systolic dysfunction progression in hypertrophic cardiomyopathy

  • By

  • Yu Li

  • Ziqi Duan

  • Jinlei Li

  • Bingxin Cheng

  • Fen Ai

  • Zhen Chen

  • June 12, 2026

  • 0 min

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  • 1

    A predictive model for early left ventricular systolic dysfunction progression (ELVSDP) in hypertrophic cardiomyopathy (HCM) patients was developed and validated.

  • 2

    Independent predictors of ELVSDP included age, smoking history, BNP levels, and left ventricular outflow tract obstruction.

  • 3

    The model demonstrated strong performance with C-indices of 0.94 and 0.93, and AUCs exceeding 0.88 at 6, 12, and 18 months.

  • 4

    Calibration curves indicated good agreement between predicted and observed outcomes, confirming the model's reliability.

  • 5

    The developed nomogram facilitates early risk stratification and individualized management for HCM patients, improving prognosis.

Original Source(s)

Prediction model for early left ventricular systolic dysfunction progression in hypertrophic cardiomyopathy

  • by Yu Li, Ziqi Duan, Jinlei Li, Bingxin Cheng, Fen Ai, Zhen Chen

  • June 12, 2026

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