Neurophysiological effects of transcranial alternating current stimulation combined with multidisciplinary rehabilitation in Parkinson’s disease

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The study investigates the neurophysiological effects of high-intensity transcranial alternating current stimulation combined with multidisciplinary rehabilitation in Parkinson's disease.
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Thirty patients were analyzed, with responders achieving significant improvement on the Unified Parkinson’s Disease Rating Scale part III.
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Responders exhibited increased temporal high beta frequencies and reduced connectivity between the default mode and sensorimotor networks.
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Changes in temporal high beta frequencies were negatively correlated with improvements in total UPDRS part III scores and rigidity subscores.
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The findings contribute to understanding the neural mechanisms of rehabilitation and neuromodulation in Parkinson's disease.

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