Circulating Biomarker Profiles Associated with Skin, Lung, and Gastrointestinal Involvement in Systemic Sclerosis

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The study analyzed 314 patients with systemic sclerosis (SSc) to characterize biomarker patterns across skin, lung, and gastrointestinal involvement.
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Patients were classified into four groups based on organ involvement: 0-Axis, 1-Axis, 2-Axis, and 3-Axis, with varying prevalence of Anti-Scl-70 positivity.
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Higher organ burden groups showed significant differences in biomarkers, including increased Anti-Scl-70 positivity and decreased albumin levels.
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Multinomial logistic regression indicated that Anti-Scl-70 positivity and lower albumin were consistently associated with higher burden groups.
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Unsupervised clustering revealed distinct biomarker-defined subgroups, highlighting structured heterogeneity in SSc beyond simple organ involvement.

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