Recurrent IDH-mutant astrocytoma WHO grade 4 diagnosed during pregnancy: case report with literature review - Takeaways - MDSpire

Recurrent IDH-mutant astrocytoma WHO grade 4 diagnosed during pregnancy: case report with literature review

  • By

  • Muratbek A. Tleubergenov

  • Altynay Bakbayeva

  • Daniyar K. Zhamoldin

  • Aidos Doskaliyev

  • Ulday M. Urazova

  • Aigul D. Tolepbergenova

  • Aisa Z. Nurpeisov

  • Zhanat T. Takenov

  • Serik Akshulakov

  • May 28, 2026

  • 0 min

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  • 1

    A 31-year-old pregnant woman was diagnosed with IDH1-mutant astrocytoma, WHO Grade 4, at 24 weeks of gestation, presenting with severe neurological symptoms.

  • 2

    The tumor exhibited a heterozygous CDKN2A/B deletion, indicating a more aggressive subtype despite the favorable IDH mutation status.

  • 3

    Emergency craniotomy and subtotal tumor resection were performed, but the tumor recurred rapidly, necessitating a cesarean section and re-craniotomy.

  • 4

    Both mother and infant survived the perioperative period, but the patient died within two years, underscoring the tumor's aggressive nature.

  • 5

    The case highlights the need for clinical guidelines for managing high-grade gliomas in pregnancy, emphasizing multidisciplinary care and timely interventions.

Original Source(s)

Recurrent IDH-mutant astrocytoma WHO grade 4 diagnosed during pregnancy: case report with literature review

  • by Muratbek A. Tleubergenov, Altynay Bakbayeva, Daniyar K. Zhamoldin, Aidos Doskaliyev, Ulday M. Urazova, Aigul D. Tolepbergenova, Aisa Z. Nurpeisov, Zhanat T. Takenov, Serik Akshulakov

  • May 28, 2026

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