Lipoprotein(a) and Risk of Treated Ventricular Arrhythmias in Heart Failure - Takeaways - MDSpire

Lipoprotein(a) and Risk of Treated Ventricular Arrhythmias in Heart Failure

  • By

  • Ramzi Ibrahim

  • Luke Dreher

  • Hussein Abdul Nabi

  • Juan Maria Farina

  • Eiad Habib

  • Hoang Nhat Pham

  • Min Choon Tan

  • Hussein A. Noureldine

  • Sammudeen Ibrahim

  • Mayurkumar Bhakta

  • Kwan Lee

  • Dan Sorajja

  • Win-Kuang Shen

  • Luis R. Scott

  • Chadi Ayoub

  • Reza Arsanjani

  • Hicham Z. El Masry

  • May 26, 2026

  • 0 min

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  • 1

    Elevated lipoprotein(a) [Lp(a)] levels are linked to increased risk of treated ventricular arrhythmias in heart failure patients.

  • 2

    In a study of 595 heart failure patients, 25.8% with elevated Lp(a) received appropriate ICD shocks compared to 9.6% with lower levels.

  • 3

    The study found no significant difference in all-cause mortality between patients with elevated and lower Lp(a) levels.

  • 4

    Elevated Lp(a) was associated with a higher rate of appropriate shocks and ATP-treated events, indicating arrhythmia risk.

  • 5

    The findings suggest elevated Lp(a) may identify an arrhythmia-prone phenotype in heart failure with reduced ejection fraction.

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