In Vitro Performance of Valved Holding Chambers in Paediatric Asthma Controller Therapy - Takeaways - MDSpire
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Evaluation of Valved Holding Chambers for Pediatric Asthma Management in Laboratory Settings

  • By

  • Laura Ojanperä

  • Lauri Lehtimäki

  • Péter Csonka

  • June 2, 2026

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  • 1

    Asthma is a leading cause of childhood morbidity, requiring daily medication, with pMDIs and VHCs recommended for preschool children.

  • 2

    Fluticasone propionate is the primary ICS for children, while combination therapy with LABA remains off-label for those under five.

  • 3

    The study evaluated fine particle delivery and total delivered dose of fluticasone and ciclesonide using three VHCs in simulated pediatric breathing.

  • 4

    A Next Generation Impactor was used to assess drug delivery, simulating a 4-year-old child's breathing pattern.

  • 5

    Statistical analyses were performed to evaluate differences in delivered doses among the VHCs using the Kruskal–Wallis test.

Original Source(s)

In Vitro Performance of Valved Holding Chambers in Paediatric Asthma Controller Therapy

  • by Laura Ojanperä, Lauri Lehtimäki, Péter Csonka

  • June 2, 2026

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