Assessment of subventricular zone irradiation in glioblastoma patients

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Glioblastoma is the most aggressive brain tumor in adults, with a poor prognosis and near-universal recurrence despite treatment.
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The subventricular zone (SVZ) may contribute to glioblastoma aggressiveness and therapeutic resistance, making its irradiation clinically significant.
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In a study of 28 patients, tumors contacting the SVZ were linked to worse overall survival and progression-free survival.
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Higher doses of incidental irradiation to the ipsilateral SVZ showed a trend toward improved overall survival in patients with SVZ-contacting tumors.
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The findings suggest a need for larger studies to explore the potential benefits of SVZ irradiation in glioblastoma treatment.

Frontiers In Oncology

by Laya K. Pillai, Maitrik J. Mehta, Ankita Parikh, Niranjan Dash, Vinay Shivhare, Sonal Patel Shah, Akash Pandya, Jayesh Kumar Singh, Krishna Prajapati, Anjali Bahuguna, Raxit Darji
May 22, 2026

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