PLAG1 rearrangement may be an oncogenic driver in a subset of sporadic cardiac myxomas: a case–control study

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Sporadic cardiac myxoma (SCM) is the most common primary heart tumor, yet its molecular pathogenesis is largely unknown.
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This study identified PLAG1 rearrangements in 35.7% of SCM cases, suggesting potential oncogenic roles in these tumors.
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No MYC amplification was detected in any SCM cases, reinforcing the benign nature of these neoplasms.
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The findings indicate molecular similarities between SCM and other tumors with abundant myxoid stroma.
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Further investigation into the genetic underpinnings of SCM is warranted based on the observed PLAG1 rearrangements.

Frontiers In Cardiovascular Medicine

by Fausto Maffini, Daniela Lepanto, Eleonora Pisa, Eisa De Camilli, Valentina Catto, Chiara Zanetti, Simona Pessina, Corrado Carbucicchio, Fabio Pagni, Nicola Fusco
May 20, 2026

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