Prognostic value of an integrated immune-inflammatory phenotype in surgically treated cervical cancer: survival modeling and immunohistochemical validation - Takeaways - MDSpire

Prognostic value of an integrated immune-inflammatory phenotype in surgically treated cervical cancer: survival modeling and immunohistochemical validation

  • By

  • Lin Ran

  • Zhaoan Lian

  • Yong Tian

  • Li Qin

  • Yingchun Xiang

  • Xiaohao Yan

  • Chengyu Shui

  • June 16, 2026

  • 0 min

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  • 1

    An integrated immune-inflammatory phenotype combining stromal TILs and SII is associated with postoperative recurrence risk in cervical cancer.

  • 2

    The study included 612 cervical cancer patients who underwent primary surgery, with significant RFS differences based on TIL and SII categories.

  • 3

    Multivariable analysis identified FIGO IIIC disease, positive margin status, and poor integrated phenotype as independent factors for worse RFS.

  • 4

    LASSO-Cox and RSF models demonstrated superior prognostic performance, with LASSO-Cox achieving the highest C-index and RSF showing the best AUC.

  • 5

    Immunohistochemical validation indicated that a favorable phenotype is characterized by higher CD8+ density and lower CD163+ density.

Original Source(s)

Prognostic value of an integrated immune-inflammatory phenotype in surgically treated cervical cancer: survival modeling and immunohistochemical validation

  • by Lin Ran, Zhaoan Lian, Yong Tian, Li Qin, Yingchun Xiang, Xiaohao Yan, Chengyu Shui

  • June 16, 2026

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