Chronic Hepatitis B and COVID-19 Clinical Outcomes in the United States: A Multisite Retrospective Cohort Study

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Chronic hepatitis B virus (HBV) infection is associated with worse clinical outcomes in patients with SARS-CoV-2 compared to those with SARS-CoV-2 alone.
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Individuals with HBV/SARS-CoV-2 had higher odds of ICU admissions and mortality, particularly those with cirrhosis.
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Vaccination against SARS-CoV-2 significantly reduced mortality rates in individuals with HBV/SARS-CoV-2.
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The pre-Delta variant period showed higher hospitalization odds compared to the Omicron variant period.
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The study highlights the need for further research on the interactions between chronic HBV and SARS-CoV-2.

Open Forum Infectious Diseases

by George A Yendewa, Temitope Olasehinde, Frank Mulindwa, Robert A Salata, Amir M Mohareb, Jeffrey M Jacobson
January 10, 2025

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