Global burden of pain in malignant bone tumors: a meta-analysis of severity and health outcomes - Takeaways - MDSpire

Global burden of pain in malignant bone tumors: a meta-analysis of severity and health outcomes

  • By

  • Guangda Zheng

  • Linghan Meng

  • Dongtao Li

  • Lu Shang

  • Juanxia Ren

  • Yanju Bao

  • July 8, 2026

  • 0 min

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  • 1

    Malignant bone tumors are highly painful and challenging to manage, significantly affecting patients' quality of life.

  • 2

    Nineteen studies were analyzed, focusing on pain management interventions like radiotherapy and bone-modifying agents.

  • 3

    Single-fraction external beam radiotherapy was found to be as effective as multi-fraction treatments for pain relief.

  • 4

    Bone-modifying agents showed mixed results, with denosumab and zoledronic acid not significantly differing in effectiveness.

  • 5

    The meta-analysis aims to assess pain severity, treatment efficacy, and health outcomes in patients with malignant bone tumors.

Original Source(s)

Global burden of pain in malignant bone tumors: a meta-analysis of severity and health outcomes

  • by Guangda Zheng, Linghan Meng, Dongtao Li, Lu Shang, Juanxia Ren, Yanju Bao

  • July 8, 2026

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