Reduction of fentanyl-induced cough by low-dose nalbuphine pretreatment during induction of general anesthesia in children: a randomized controlled trial - Takeaways - MDSpire

Reduction of fentanyl-induced cough by low-dose nalbuphine pretreatment during induction of general anesthesia in children: a randomized controlled trial

  • By

  • Pan He

  • Yingying Tao

  • Yang Shen

  • Zhezhe Peng

  • Mazhong Zhang

  • Ying Sun

  • June 10, 2026

  • 0 min

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  • 1

    Low-dose nalbuphine pretreatment significantly reduces the incidence of fentanyl-induced cough during general anesthesia in pediatric patients.

  • 2

    The study involved 100 children aged 2–12 years, randomly assigned to receive nalbuphine or saline before fentanyl administration.

  • 3

    The incidence of fentanyl-induced cough was 18% in the nalbuphine group compared to 54% in the control group, showing a significant risk difference.

  • 4

    Cough severity was statistically lower in the nalbuphine group, while no significant differences in vital signs or adverse events were observed.

  • 5

    This study is the first randomized controlled trial investigating nalbuphine's effect on fentanyl-induced cough in children.

Original Source(s)

Reduction of fentanyl-induced cough by low-dose nalbuphine pretreatment during induction of general anesthesia in children: a randomized controlled trial

  • by Pan He, Yingying Tao, Yang Shen, Zhezhe Peng, Mazhong Zhang, Ying Sun

  • June 10, 2026

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