Case Report: Malignant transformation of deep infiltrating endometriosis: a report of two cases and literature review - Takeaways - MDSpire

Case Report: Malignant transformation of deep infiltrating endometriosis: a report of two cases and literature review

  • By

  • Yue Gu

  • Xuanxuan Zhao

  • Yongheng Shi

  • Zhijun Hu

  • Qing Liu

  • Hong Zhu

  • Peiquan Li

  • Kaijiang Liu

  • June 18, 2026

  • 0 min

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  • 1

    Deep infiltrating endometriosis (DIE) can rarely undergo malignant transformation, leading to endometrioid adenocarcinoma.

  • 2

    Two cases of long-standing DIE progressing to endometrioid adenocarcinoma were reported, both complicated by hydronephrosis.

  • 3

    Diagnosis of malignant transformation in DIE is challenging due to nonspecific clinical manifestations and overlap with benign conditions.

  • 4

    A multidisciplinary approach involving complete surgical resection and adjuvant therapy is recommended for managing malignant DIE.

  • 5

    Literature review identified 57 additional cases of malignant transformation from DIE, predominantly affecting the rectosigmoid colon and vagina.

Original Source(s)

Case Report: Malignant transformation of deep infiltrating endometriosis: a report of two cases and literature review

  • by Yue Gu, Xuanxuan Zhao, Yongheng Shi, Zhijun Hu, Qing Liu, Hong Zhu, Peiquan Li, Kaijiang Liu

  • June 18, 2026

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