Delayed Platelet Engraftment and Ongoing Pulmonary Infection Following Haploidentical Allogeneic Hematopoietic Stem Cell Transplantation: A Case Study - Takeaways - MDSpire

Delayed Platelet Engraftment and Ongoing Pulmonary Infection Following Haploidentical Allogeneic Hematopoietic Stem Cell Transplantation: A Case Study

  • By

  • Ying He

  • Yaxin Xiong

  • Juanjuan Zhang

  • Xinyu Gan

  • Fangyi Fan

  • Hai Yi

  • April 24, 2026

  • 0 min

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  • 1

    A 52-year-old woman experienced delayed platelet engraftment and severe pulmonary infections following haploidentical HSCT.

  • 2

    She developed Rhizopus microsporus infection on day +1 and Pseudomonas aeruginosa septic shock on day +106.

  • 3

    Neutrophil engraftment occurred by day +13, but platelet engraftment was delayed until day +40.

  • 4

    Thrombopoietin receptor agonists showed minimal response, and the patient died 6 months post-transplant.

  • 5

    The case underscores the importance of infection control prior to PGF-directed therapy in post-transplant patients.

Original Source(s)

Delayed Platelet Engraftment and Ongoing Pulmonary Infection Following Haploidentical Allogeneic Hematopoietic Stem Cell Transplantation: A Case Study

  • by Ying He, Yaxin Xiong, Juanjuan Zhang, Xinyu Gan, Fangyi Fan, Hai Yi

  • April 24, 2026

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