Pharmacovigilance profiles of three generations of mineralocorticoid receptor antagonists and network toxicology analysis - Takeaways - MDSpire

Pharmacovigilance profiles of three generations of mineralocorticoid receptor antagonists and network toxicology analysis

  • By

  • Hai-Hong Lin

  • Wen-Hui Cui

  • Feng Xu

  • Jia-Yi He

  • Liu-Cheng Li

  • Jun-Jie Xu

  • Xin Jiang

  • Kai-Li Mao

  • June 23, 2026

  • 0 min

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  • 1

    This study analyzed post-marketing safety profiles of spironolactone, eplerenone, and finerenone using 11,556 reports from the FAERS database.

  • 2

    Spironolactone showed the broadest safety profile, with notable adverse events including congenital malformations and severe cutaneous reactions.

  • 3

    Eplerenone's safety profile was more concentrated, indicating serious cardiac incidents and renal/hepatic failure.

  • 4

    Finerenone exhibited a specific safety profile, primarily associated with renal and metabolic adverse events.

  • 5

    Network toxicology assessments linked drug-specific molecular targets to essential pathways, highlighting the need for individualized safety surveillance.

Original Source(s)

Pharmacovigilance profiles of three generations of mineralocorticoid receptor antagonists and network toxicology analysis

  • by Hai-Hong Lin, Wen-Hui Cui, Feng Xu, Jia-Yi He, Liu-Cheng Li, Jun-Jie Xu, Xin Jiang, Kai-Li Mao

  • June 23, 2026

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