Potential neuroprotective and anticonvulsant effects of Ganoderma lucidum ethanol extract and its impact on affective comorbidities associated with pentylenetetrazol kindling model of epilepsy: behavioral, biochemical and histological studies - Takeaways - MDSpire

Potential neuroprotective and anticonvulsant effects of Ganoderma lucidum ethanol extract and its impact on affective comorbidities associated with pentylenetetrazol kindling model of epilepsy: behavioral, biochemical and histological studies

  • By

  • Itto Rahou Abdessamad

  • Bikjdaouene Leila

  • Bahbiti Youssef

  • Sqalli Houssaini Youssef

  • El Mekhlouf Youssef

  • Azeroil Fatima

  • Doumar Hanan

  • Dimaoui Amal

  • El-Hessni Aboubaker

  • Mesfioui Abdelhalem

  • July 10, 2026

  • 0 min

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  • 1

    Ganoderma lucidum extract (GLE) significantly reduces the severity of convulsive seizures in a pentylenetetrazol-induced epilepsy model.

  • 2

    GLE alleviates anxious and depressive behaviors in rats, as evidenced by behavioral tests such as the open field and forced swim tests.

  • 3

    Biochemical analysis shows that GLE reduces oxidative stress markers, including malondialdehyde and nitric oxide, while restoring antioxidant enzyme activities.

  • 4

    Histological studies indicate that GLE mitigates neurodegeneration in the prefrontal cortex, supporting its neuroprotective properties.

  • 5

    The findings suggest that GLE may have therapeutic potential for managing epilepsy and its comorbid affective disorders.

Original Source(s)

Potential neuroprotective and anticonvulsant effects of Ganoderma lucidum ethanol extract and its impact on affective comorbidities associated with pentylenetetrazol kindling model of epilepsy: behavioral, biochemical and histological studies

  • by Itto Rahou Abdessamad, Bikjdaouene Leila, Bahbiti Youssef, Sqalli Houssaini Youssef, El Mekhlouf Youssef, Azeroil Fatima, Doumar Hanan, Dimaoui Amal, El-Hessni Aboubaker, Mesfioui Abdelhalem

  • July 10, 2026

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