UTI Prophylaxis Raises Resistance Risk

Study finds more resistance on culture, no significant rise in severe infections

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Prophylactic antibiotics for recurrent UTIs increased antimicrobial resistance in urine cultures but did not significantly raise hospital admissions for resistant infections.
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In a study of 48,297 women, 31% of those on prophylaxis showed resistance to at least one antibiotic compared to 24% not receiving prophylaxis.
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Resistance to two or more antibiotics was found in 22% of the prophylaxis group versus 14% in the non-prophylaxis group.
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The study highlights a distinction between microbiological resistance and clinical outcomes, with no significant increase in serious infections.
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Limitations include observational design, potential confounding factors, and variability in urine culture testing and resistance reporting.

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