Diagnostic yield, safety, and molecular-era clinical utility of stereotactic biopsy for brainstem lesions: a contemporary systematic review and meta-analysis - Takeaways - MDSpire
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Evaluating the Diagnostic Effectiveness, Safety, and Clinical Relevance of Stereotactic Biopsy for Brainstem Lesions: A Systematic Review and Meta-Analysis of Recent Evidence

  • By

  • Hanqiang Du

  • Jiajia Wang

  • Qicheng Liu

  • Gaoquan Luo

  • September 9, 2026

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  • 1

    Stereotactic biopsy for brainstem lesions has a high diagnostic yield of 93.5%, based on a systematic review of 76 reports.

  • 2

    Overall complications from stereotactic biopsy were reported at 10.5%, with permanent neurological morbidity at 0.83% and procedure-related mortality at 0.30%.

  • 3

    The study included 71 full-text articles and 5 abstract reports, with 55 independent studies contributing to quantitative synthesis.

  • 4

    Diagnostic yield was inversely associated with study size, with a yield of 93.7% when excluding studies with fewer than 20 participants.

  • 5

    Differences in population, technique, and outcome definitions necessitate cautious interpretation of results rather than universal recommendations.

Original Source(s)

Diagnostic yield, safety, and molecular-era clinical utility of stereotactic biopsy for brainstem lesions: a contemporary systematic review and meta-analysis

  • by Hanqiang Du, Jiajia Wang, Qicheng Liu, Gaoquan Luo

  • September 9, 2026

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