Observational study on initiation of dapagliflozin in heart failure with reduced ejection fraction in the United Kingdom - Takeaways - MDSpire
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Real-World Analysis of Dapagliflozin Initiation in Patients with Heart Failure and Reduced Ejection Fraction in the UK

  • By

  • Steven Coombs

  • Angela Tithecott

  • Cristina Thiebaud

  • Parminder Chaggar

  • Diane Barker

  • Prithwish Banerjee

  • Henry Oluwasefunmi Savage

  • Alastair Gray

  • Geraint Jenkins

  • Mohammad Albarjas

  • Liz Hennessy

  • Joanna De Courcy

  • Hannah Wallis

  • Thom Dewar

  • Reece Manuell

  • Sophie Barlow

  • Samuel Adamsson Eryd

  • Jil Billy Mamza

  • Tamsin Morris

  • September 8, 2026

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  • 1

    The study followed 237 UK adults with heart failure and reduced ejection fraction who initiated dapagliflozin.

  • 2

    Dapagliflozin discontinuation occurred at a rate of 11.7/100 patient-years, primarily due to adverse drug reactions.

  • 3

    Mean KCCQ-23 scores improved from 67.6 to 71.6, indicating a positive change in quality of life over 12 months.

  • 4

    High treatment adherence was observed, with MARS-5 scores averaging at least 23.1 throughout the study.

  • 5

    Overall work impairment decreased from 31.2% to 16.3%, while activity impairment slightly reduced from 40.5% to 36.8%.

Original Source(s)

Observational study on initiation of dapagliflozin in heart failure with reduced ejection fraction in the United Kingdom

  • by Steven Coombs, Angela Tithecott, Cristina Thiebaud, Parminder Chaggar, Diane Barker, Prithwish Banerjee, Henry Oluwasefunmi Savage, Alastair Gray, Geraint Jenkins, Mohammad Albarjas, Liz Hennessy, Joanna De Courcy, Hannah Wallis, Thom Dewar, Reece Manuell, Sophie Barlow, Samuel Adamsson Eryd, Jil Billy Mamza, Tamsin Morris

  • September 8, 2026

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