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1
The blood-brain barrier (BBB) protects the brain from toxins but complicates drug delivery, restricting most therapeutics from entering.
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2
Recent research highlights the BBB's molecular and cellular architecture, revealing its heterogeneity across brain regions and the arteriovenous axis.
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3
Changes in the BBB occur with aging, neurodegeneration, and brain injuries, impacting transport mechanisms and disease progression.
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4
Novel drug delivery strategies are being developed to enhance the transport of therapeutics across the BBB, addressing significant treatment challenges.
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5
Advancements in molecular technologies are improving our understanding of the BBB, paving the way for innovative therapeutic approaches and restoration strategies.
