A distinct gastrointestinal symptom profile characterizes clinically relevant fatigue in systemic sclerosis - Takeaways - MDSpire
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A Unique Gastrointestinal Symptom Profile Distinguishes Clinically Significant Fatigue in Systemic Sclerosis

  • By

  • Francesco Bonomi

  • Silvia Peretti

  • Giulia Bandini

  • Veronica De Silvestri

  • Cristiano Barbetta

  • Ilenia Mallia

  • Khadija El Aoufy

  • Ginevra Fiori

  • Serena Guiducci

  • Alberto Moggi Pignone

  • Zsuzsanna H. McMahan

  • Marco Matucci-Cerinic

  • Cosimo Bruni

  • Michael Hughes

  • Silvia Bellando Randone

  • September 8, 2026

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  • 1

    Fatigue is a prevalent and disabling symptom in systemic sclerosis (SSc), impacting quality of life and functional capacity.

  • 2

    Gastrointestinal involvement is a significant correlate of fatigue in SSc, but the relationship with specific GI symptoms remains unclear.

  • 3

    The study aims to identify individual GI manifestations associated with clinically relevant fatigue in SSc patients.

  • 4

    A cross-sectional observational study was conducted among SSc patients to evaluate fatigue and GI symptom patterns.

  • 5

    Participants were assessed using the FACIT-Fatigue questionnaire and various clinical measures to understand fatigue's correlates.

Original Source(s)

A distinct gastrointestinal symptom profile characterizes clinically relevant fatigue in systemic sclerosis

  • by Francesco Bonomi, Silvia Peretti, Giulia Bandini, Veronica De Silvestri, Cristiano Barbetta, Ilenia Mallia, Khadija El Aoufy, Ginevra Fiori, Serena Guiducci, Alberto Moggi Pignone, Zsuzsanna H. McMahan, Marco Matucci-Cerinic, Cosimo Bruni, Michael Hughes, Silvia Bellando Randone

  • September 8, 2026

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