Associations of static anatomical geometry with planned dosimetric endpoints in prostate radiotherapy: a multicenter study

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The study analyzed 37 patients from four centers to investigate the relationship between anatomical geometry and dosimetric outcomes in prostate radiotherapy.
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Bladder volume and longitudinal extent were consistently associated with multiple bladder dose-volume histogram (DVH) endpoints in the main cohort.
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Near-zero bladder D2cc values indicated geometric separation from high-dose regions rather than errors in dose reconstruction or DVH computation.
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The same processing workflow was successfully applied to an independent institutional DICOM cohort, demonstrating its real-world applicability.
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The study emphasizes the importance of reproducible geometric features in evaluating planned dosimetric endpoints in contemporary prostate radiotherapy.

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