A gene-expression signature defines a subtype of Stomach Adenocarcinomas with low levels of Claudins and a high ratio of NF-YA long/NF-YA short splicing variants

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Stomach Adenocarcinoma (STAD) is heterogeneous and has a poor survival rate, classified into various subtypes based on histological and molecular features.
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Claudins are proteins involved in cell interactions, with low expression linked to aggressive cancers, including STAD, breast cancer, and bladder cancer.
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A distinct Claudinlow subtype in STAD was identified based on a 24-gene transcriptomic signature, indicating unique molecular characteristics.
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The NF-Y transcription factor regulates gene expression, with a high NF-YA long/NF-YA short ratio associated with poor clinical outcomes in aggressive cancers.
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The study compares gene signatures to refine STAD classification, utilizing RNA-seq data from multiple sources to enhance understanding of tumor subtypes.

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