Update on Selected Adverse Events of Concern Following Immunization With Acellular Pertussis Vaccines, a Narrative Review - Takeaways - MDSpire

Review of Notable Adverse Events Associated with Acellular Pertussis Vaccination: A Narrative Overview

  • By

  • Lennart Nilsson

  • Jann Storsaeter

  • July 12, 2026

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  • 1

    Acellular pertussis vaccines were developed in the 1970s and 1980s, showing proven efficacy in clinical trials.

  • 2

    Systematic surveillance for adverse events following immunization (AEFI) was initiated when acellular vaccines were introduced.

  • 3

    Mild adverse events from acellular pertussis vaccines include local reactions and systemic symptoms, with lower rates than whole-cell vaccines.

  • 4

    Moderate adverse events include fever, extensive limb swelling, and hypotonic hyporesponsive episodes, particularly in infants.

  • 5

    Hypotonic hyporesponsive episodes typically occur within 48 hours of vaccination, primarily affecting infants under 6 months.

Original Source(s)

Update on Selected Adverse Events of Concern Following Immunization With Acellular Pertussis Vaccines, a Narrative Review

  • by Lennart Nilsson, Jann Storsaeter

  • July 12, 2026

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