Echocardiography-derived hemodynamic forces in cardiac resynchronization therapy: association with reverse remodeling and long-term outcomes - Takeaways - MDSpire
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Hemodynamic Forces from Echocardiography in Cardiac Resynchronization Therapy: Links to Reverse Remodeling and Long-Term Prognosis

  • By

  • Roberto Tarantini

  • Willem Gerrits

  • Cheyenne S.L. Chiu

  • Leonie Smit

  • Gilbert Heltzel

  • Luuk H.G.A. Hopman

  • Philippe C. Wouters

  • Maarten J. Cramer

  • Frebus J. van Slochteren

  • Rene van Es

  • Alexander H. Maass

  • Michiel Rienstra

  • Cornelis P. Allaart

  • Kevin Vernooy

  • Antonius M.W. van Stipdonk

  • Frederik J. de Lange

  • Dorien Laenens

  • Philippe van Rosendael

  • Jeroen J. Bax

  • Nina Ajmone Marsan

  • September 9, 2026

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  • 1

    Echocardiography-derived hemodynamic force (HDF) parameters provide additional insight into left ventricular mechanics in patients undergoing cardiac resynchronization therapy (CRT).

  • 2

    Adding baseline systolic angle to established markers significantly improves model fit for CRT response but does not significantly improve discrimination.

  • 3

    CRT responders show significant improvements in HDF parameters at 6 months after implantation, while nonresponders show no significant changes.

  • 4

    Baseline systolic angle is independently associated with the composite endpoint of all-cause mortality or cardiovascular hospitalization over a median follow-up of 9.3 years.

  • 5

    Further prospective research is needed to determine whether HDF assessment improves clinical risk prediction in patients undergoing CRT.

Original Source(s)

Echocardiography-derived hemodynamic forces in cardiac resynchronization therapy: association with reverse remodeling and long-term outcomes

  • by Roberto Tarantini, Willem Gerrits, Cheyenne S.L. Chiu, Leonie Smit, Gilbert Heltzel, Luuk H.G.A. Hopman, Philippe C. Wouters, Maarten J. Cramer, Frebus J. van Slochteren, Rene van Es, Alexander H. Maass, Michiel Rienstra, Cornelis P. Allaart, Kevin Vernooy, Antonius M.W. van Stipdonk, Frederik J. de Lange, Dorien Laenens, Philippe van Rosendael, Jeroen J. Bax, Nina Ajmone Marsan

  • September 9, 2026

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