Biology of p53 protein isoforms and their significance in hematological malignancies

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The TP53 gene produces diverse p53 protein isoforms that influence tumor progression and treatment response in hematological cancers.
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N-terminally truncated and C-terminally spliced p53 isoforms can alter transcriptional programs affecting apoptosis and DNA repair.
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TP53 mutations are less common in hematological malignancies, occurring in 10-30% of patients across various types.
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Isoform expression can occur independently of TP53 mutation status, complicating predictions of cancer progression.
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Standardized assays and larger studies are needed to validate the clinical utility of p53 isoform profiling in risk assessment.

Frontiers In Oncology

by Anna Maria Janik, Zuzanna Tracz-Gaszewska, Irena Misiewicz-Krzemińska, Krzysztof Jamroziak
June 2, 2026

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