Late-onset temporal lobe epilepsy: insights from brain atrophy and Alzheimer’s disease biomarkers - Takeaways - MDSpire

Late-onset temporal lobe epilepsy: insights from brain atrophy and Alzheimer’s disease biomarkers

  • By

  • Alice Ballerini

  • Niccolò Biagioli

  • Chiara Carbone

  • Annalisa Chiari

  • Manuela Tondelli

  • Giulia Vinceti

  • Roberta Bedin

  • Marcella Malagoli

  • Maurilio Genovese

  • Simona Scolastico

  • Giada Giovannini

  • Matteo Pugnaghi

  • Niccolò Orlandi

  • Louis Lemieux

  • Stefano Meletti

  • Giovanna Zamboni

  • Anna Elisabetta Vaudano

  • June 25, 2024

  • 0 min

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  • 1

    Late-onset temporal lobe epilepsy (LO-TLE) may have neurodegenerative origins and overlaps with Alzheimer's disease (AD).

  • 2

    The study enrolled 20 LO-TLE patients with a mean disease duration of 1.8 years and compared them to control groups.

  • 3

    CSF biomarkers in LO-TLE patients were normal, differing significantly from those in patients with mild cognitive impairment due to AD.

  • 4

    Cortical atrophy patterns in LO-TLE patients were similar to healthy controls, contrasting with widespread injuries in mild cognitive impairment patients.

  • 5

    The findings suggest that biological phenotyping of LO-TLE using CSF biomarkers is essential for understanding cortical and subcortical atrophy.

Original Source(s)

Late-onset temporal lobe epilepsy: insights from brain atrophy and Alzheimer’s disease biomarkers

  • by Alice Ballerini, Niccolò Biagioli, Chiara Carbone, Annalisa Chiari, Manuela Tondelli, Giulia Vinceti, Roberta Bedin, Marcella Malagoli, Maurilio Genovese, Simona Scolastico, Giada Giovannini, Matteo Pugnaghi, Niccolò Orlandi, Louis Lemieux, Stefano Meletti, Giovanna Zamboni, Anna Elisabetta Vaudano

  • June 25, 2024

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