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1
Idiopathic normal pressure hydrocephalus (iNPH) often coexists with Alzheimer's disease (AD) in 25–67% of cases, necessitating simultaneous treatment.
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2
Lecanemab, an anti-amyloid-β antibody therapy, is recommended for early-stage AD and may be used alongside shunt surgery for patients with iNPH and AD.
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3
In a case study, an 84-year-old woman with iNPH and AD improved cognitively after undergoing lumboperitoneal shunt surgery following lecanemab treatment.
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4
Another case involved an 84-year-old woman who received ventriculoperitoneal shunt surgery and lecanemab therapy, demonstrating the need for careful treatment sequencing.
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5
The safety of combining shunt surgery with lecanemab therapy remains uncertain, particularly regarding the risk of amyloid-related imaging abnormalities.
