Comparative Analysis of High and Low Positive End-Expiratory Pressure in One-Lung Ventilation for Thoracic Surgical Procedures: A Systematic Review and Meta-Analysis

1

Higher fixed PEEP during one-lung ventilation significantly increases the risk of intraoperative hypotension without reducing postoperative pulmonary complications.
2

The systematic review included eight RCTs with 2,747 patients, assessing the effects of higher vs. lower fixed PEEP during thoracic surgery.
3

Higher PEEP was associated with a 2.16-fold increased risk of intraoperative hypotension, indicating moderate certainty in the findings.
4

New-onset arrhythmia occurred more frequently with higher PEEP, while rescue hypoxaemia interventions were less frequent.
5

The study suggests caution in routinely applying higher fixed PEEP during OLV, advocating for future research on individualized PEEP titration strategies.

1