Association of perioperative patient characteristics, intraoperative fluid management, and vasopressors with anastomotic leakage after Ivor-Lewis esophagectomy—a single center retrospective cohort - Takeaways - MDSpire

Association of perioperative patient characteristics, intraoperative fluid management, and vasopressors with anastomotic leakage after Ivor-Lewis esophagectomy—a single center retrospective cohort

  • By

  • Chelsea Yap

  • Rachel Warner

  • Amie L. Hoefnagel

  • Saurin Shah

  • Paul D. Mongan

  • Ziad Awad

  • February 17, 2026

  • 0 min

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  • 1

    Anastomotic leakage (AL) is a serious complication of Ivor-Lewis esophagectomy, with reported rates between 5% and 30% historically.

  • 2

    Risk factors for AL include poor nutritional status, medical comorbidities, neoadjuvant therapy, and technical surgical considerations.

  • 3

    Individualized, goal-directed fluid management during surgery is associated with lower AL rates compared to liberal fluid replacement.

  • 4

    Intraoperative vasopressor strategies may influence conduit perfusion and should be further investigated for their impact on AL.

  • 5

    This study aims to identify modifiable factors affecting AL to improve perioperative protocols and reduce associated healthcare costs.

Original Source(s)

Association of perioperative patient characteristics, intraoperative fluid management, and vasopressors with anastomotic leakage after Ivor-Lewis esophagectomy—a single center retrospective cohort

  • by Chelsea Yap, Rachel Warner, Amie L. Hoefnagel, Saurin Shah, Paul D. Mongan, Ziad Awad

  • February 17, 2026

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