Evaluation and Mechanistic Investigation of Antitumor Compounds from Dioscorea nipponica Makino subsp. rosthornii Through Spectrum-Effect Relationship Analysis - Takeaways - MDSpire

Evaluation and Mechanistic Investigation of Antitumor Compounds from Dioscorea nipponica Makino subsp. rosthornii Through Spectrum-Effect Relationship Analysis

  • By

  • Mengjia Liang

  • Moyu Shen

  • Yuxuan Wang

  • Pengxin Fan

  • Yuguang Zheng

  • Haiyang Wang

  • Jingcun Sun

  • Songsong Jing

  • April 29, 2026

  • 0 min

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  • 1

    Dioscorea nipponica Makino subsp. rosthornii was analyzed for antitumor compounds using UPLC-QTOF-MS, identifying 23 distinct chemical constituents.

  • 2

    The extract from D. nipponica Makino subsp. rosthornii significantly inhibited proliferation, migration, and invasion of A549 lung cancer cells.

  • 3

    Spectrum-effect relationship analysis identified protodioscin, diosgenin, and gracillin as potential antitumor compounds from the extract.

  • 4

    Mechanistic studies revealed that these saponins reduce N-cadherin and MMP2 expression while increasing E-cadherin in A549 cells.

  • 5

    The findings support the potential application of D. nipponica Makino subsp. rosthornii in cancer therapy based on its active constituents.

Original Source(s)

Evaluation and Mechanistic Investigation of Antitumor Compounds from Dioscorea nipponica Makino subsp. rosthornii Through Spectrum-Effect Relationship Analysis

  • by Mengjia Liang, Moyu Shen, Yuxuan Wang, Pengxin Fan, Yuguang Zheng, Haiyang Wang, Jingcun Sun, Songsong Jing

  • April 29, 2026

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