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1
CD38 is a transmembrane protein that degrades NAD+ and is expressed in various immune cells, including NK cells.
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2
In rheumatoid arthritis, CD38+ NK cells produce high levels of IFN-γ and low levels of TGF-β, disrupting immune tolerance.
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3
In colorectal cancer, CD38+ NK cells produce low levels of IFN-γ and high levels of TGF-β, promoting Treg differentiation.
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4
CD38+ NK cells exhibit opposing regulatory effects on immune balance, influenced by their CD16 expression.
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5
The expression of HSPA1B, a tumor suppressor, is decreased in CD38+ NK cells from colorectal cancer patients.
