Body Composition by DXA in Patients with Klinefelter and Kallmann Syndrome: The Kama Study - Takeaways - MDSpire

Body Composition by DXA in Patients with Klinefelter and Kallmann Syndrome: The Kama Study

  • By

  • Caterina Buoso

  • Andrea Delbarba

  • Matteo Riva

  • Giulia Artifoni

  • Elisa Gatta

  • Davide Farina

  • Eugenia Quiros-Roldan

  • Alberto Ferlin

  • Carlo Cappelli

  • October 10, 2025

  • 0 min

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  • 1

    Klinefelter syndrome and Kallmann syndrome are genetic disorders characterized by low testosterone levels and differing gonadotrophin profiles.

  • 2

    The study assessed body composition in 50 patients, revealing significant differences in lean mass between those with Klinefelter and Kallmann syndromes.

  • 3

    Patients with Kallmann syndrome exhibited higher appendicular lean mass index (ALMI) values compared to those with Klinefelter syndrome.

  • 4

    Radiologic sarcopenic obesity was identified in 14% of patients, with a higher prevalence in Klinefelter syndrome.

  • 5

    The study found an inverse association between follicle-stimulating hormone levels and ALMI, suggesting FSH's role in muscle mass modulation.

Original Source(s)

Body Composition by DXA in Patients with Klinefelter and Kallmann Syndrome: The Kama Study

  • by Caterina Buoso, Andrea Delbarba, Matteo Riva, Giulia Artifoni, Elisa Gatta, Davide Farina, Eugenia Quiros-Roldan, Alberto Ferlin, Carlo Cappelli

  • October 10, 2025

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