A systematic review of semaglutide-associated kidney injury case reports - Takeaways - MDSpire

A systematic review of semaglutide-associated kidney injury case reports

  • By

  • Xian Xiu

  • Pan-pan Zheng

  • Yang Li

  • Meng Du

  • Xi Min

  • Xiaohua Pang

  • Lili Zhang

  • Jingtao Liu

  • Zhe Zhao

  • Zan-chao Liu

  • Cai-Xia Feng

  • June 1, 2026

  • 0 min

Share

  • 1

    This systematic review analyzed 20 cases of kidney injury linked to semaglutide use, highlighting its potential adverse drug reactions.

  • 2

    Patients included in the review ranged from 29 to 83 years old, with a majority receiving semaglutide for weight loss or blood sugar control.

  • 3

    Adverse drug reactions reported included acute kidney injury, acute renal failure, and acute interstitial nephritis, occurring at standard doses.

  • 4

    Twelve cases were diagnosed through renal biopsy, while eight were diagnosed based on renal function parameters.

  • 5

    Seventeen patients showed improvement or recovery after treatment, while outcomes were not reported for two patients, and one did not recover.

Original Source(s)

A systematic review of semaglutide-associated kidney injury case reports

  • by Xian Xiu, Pan-pan Zheng, Yang Li, Meng Du, Xi Min, Xiaohua Pang, Lili Zhang, Jingtao Liu, Zhe Zhao, Zan-chao Liu, Cai-Xia Feng

  • June 1, 2026

Related Content

Editorial: Addressing the Challenges of Diabetes Complications and Exploring Innovative Approaches

Utilizing Machine Learning to Identify Risk Factors for Diabetic Microvascular Complications and Develop a Predictive Model with Gradient Boosting Decision Trees