The converging paths to hippocampal sclerosis of ageing: insights from LATE-NC and vascular disease

1

Hippocampal sclerosis of ageing (HS-A) is linked to neuronal loss and gliosis in the hippocampal CA1 region and subiculum in elderly individuals.
2

LATE-NC is significantly associated with HS-A, with a dose-dependent increase observed in patients with advanced LATE-NC stages.
3

The study suggests that LATE-NC may causally influence HS-A, while associations with Alzheimer’s disease neuropathologic changes diminish when adjusted for LATE-NC.
4

Global cerebrovascular disease also independently correlates with HS-A, indicating multiple pathogenic pathways contributing to the condition.
5

The findings highlight the need for in vivo biomarkers for LATE-NC and underscore cerebrovascular health as a potential therapeutic target.

1