From vector to allergen: exploring the immunology of tick-triggered α-Gal syndrome

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α-Gal syndrome (AGS) is a food allergy linked to tick bites, characterized by delayed hypersensitivity to mammalian meat products.
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IgE antibodies specific to the carbohydrate α-Gal are responsible for allergic reactions in AGS, differing from typical food allergies.
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Tick bites are the primary sensitization route for AGS, with various tick species implicated in different global regions.
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The clinical manifestations of AGS can vary widely among individuals and episodes, necessitating increased awareness among healthcare providers.
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Understanding the immunological mechanisms of α-Gal sensitization is crucial for developing diagnostic biomarkers and prevention strategies.

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