Fibrinogen-like protein 2 regulates inflammatory and metabolic reprogramming of airway smooth muscle cells through PI3K/Akt activation - Takeaways - MDSpire

Fibrinogen-like protein 2 regulates inflammatory and metabolic reprogramming of airway smooth muscle cells through PI3K/Akt activation

  • By

  • Bo Zhao

  • Yanran Che

  • May 12, 2026

  • 0 min

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  • 1

    Fibrinogen-like protein 2 (FGL2) is implicated in airway smooth muscle cell (ASMC) dysfunction and modulates inflammatory responses.

  • 2

    PDGF-BB stimulation significantly increases FGL2 expression in ASMCs, enhancing proliferation, migration, and inflammation.

  • 3

    Silencing FGL2 reduces PI3K/Akt pathway activation, leading to decreased ASMC proliferation, migration, and inflammatory cytokine production.

  • 4

    FGL2 knockdown also inhibits glycolytic reprogramming in ASMCs, affecting glucose consumption and lactate production.

  • 5

    These findings suggest FGL2 as a potential therapeutic target for chronic airway diseases by limiting airway remodeling.

Original Source(s)

Fibrinogen-like protein 2 regulates inflammatory and metabolic reprogramming of airway smooth muscle cells through PI3K/Akt activation

  • by Bo Zhao, Yanran Che

  • May 12, 2026

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