Mineralocorticoid receptors are implicated in the initial steps of the cardiorenal damage induced by ethanol - Takeaways - MDSpire

Mineralocorticoid receptors are implicated in the initial steps of the cardiorenal damage induced by ethanol

  • By

  • Thales M. H. Dourado

  • Gustavo F. Pimenta

  • Barbara M. Marchetti

  • Alessandra O. Silva

  • Carlos R. Tirapelli

  • June 23, 2026

  • 0 min

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  • 1

    Ethanol exposure induces oxidative stress, leading to cardiorenal injury through increased reactive oxygen species generation.

  • 2

    Mineralocorticoid receptor activation mediates the pro-oxidative effects of ethanol in cardiac and renal tissues.

  • 3

    Blockade of mineralocorticoid receptors with potassium canrenoate prevents ethanol-induced increases in lipoperoxidation and superoxide levels.

  • 4

    Ethanol treatment elevates hydrogen peroxide levels in the renal cortex, which is mitigated by mineralocorticoid receptor antagonism.

  • 5

    Ethanol enhances cardiac thromboxane B2 and renal prostaglandin E2 levels, effects that are reversed by mineralocorticoid receptor blockade.

Original Source(s)

Mineralocorticoid receptors are implicated in the initial steps of the cardiorenal damage induced by ethanol

  • by Thales M. H. Dourado, Gustavo F. Pimenta, Barbara M. Marchetti, Alessandra O. Silva, Carlos R. Tirapelli

  • June 23, 2026

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